# HISTORY 21 Feb 2017: Saved by donghuili using Paint 2.0-beta14 # molecular_function 20170221: Opisthokonta_PTN001002058 has function signal transducer activity (GO:0004871) 20170221: Eumetazoa_PTN001002059 has function WW domain binding (GO:0050699) # cellular_component 20170221: Opisthokonta_PTN001002058 is found in cytoplasm (GO:0005737) 20170221: node_PTN000333702 is found in Golgi apparatus (GO:0005794) 20170221: node_PTN000333702 is found in perinuclear region of cytoplasm (GO:0048471) # biological_process 20170221: node_PTN000333702 participates in negative regulation of gene expression (GO:0010629) 20170221: node_PTN000333702 participates in negative regulation of protein transport (GO:0051224) 20170221: node_PTN000333702 participates in negative regulation of transporter activity (GO:0032410) 20170221: node_PTN000333702 participates in positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 20170221: node_PTN000333702 participates in positive regulation of protein ubiquitination (GO:0031398) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).