# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20150706: Eukaryota_PTN000327519 is found in catalytic step 2 spliceosome (GO:0071013) 20150706: Eukaryota_PTN000327519 is found in Prp19 complex (GO:0000974) 20150706: Eukaryota_PTN000327519 is found in catalytic step 1 spliceosome (GO:0071012) 20150706: Eukaryota_PTN000327519 is found in prespliceosome (GO:0071010) 20150706: Eukaryota_PTN000327519 is found in post-mRNA release spliceosomal complex (GO:0071014) # biological_process 20150706: Eukaryota_PTN000327519 participates in mRNA splicing, via spliceosome (GO:0000398) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains SYF2, which is characterized in S. cerevisiae as being a member of the PRP19 complex which is involved in assembly of the spliceosome, subsequent rearrangements to produce catalyticly active forms, and disassembly. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).