# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150728: Eukaryota_PTN000322838 has function protein complex scaffold (GO:0032947) # cellular_component 20150728: Eukaryota_PTN000322838 is found in cytoplasmic mRNA processing body (GO:0000932) 20150728: Eukaryota_PTN000322838 is found in CCR4-NOT core complex (GO:0030015) # biological_process 20150728: Eukaryota_PTN000322838 participates in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288) 20150728: Eukaryota_PTN000322838 participates in negative regulation of translation (GO:0017148) 20150728: Mammalia_PTN000322847 participates in regulation of stem cell population maintenance (GO:2000036) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Review PMID:22027279 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).