# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component # biological_process 20160302: Eukaryota_PTN000322792 participates in mRNA 5'-splice site recognition (GO:0000395) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family has a duplication node at the top with two subclades, SFSWAP & CLASRP. SFSWAP is characterized as being involved in regulation of alternative splicing via its role in selection of the 5' splice site. CLASRP does not appear to be experimentally characterized. With only process information, I have only made propagations to the SFSWAP subclade, not to the root duplication node, as I do not feel confident making any propagations to the CLASRP subclade based on the limited existing experimental characterization. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).