# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20140612: Eukaryota_PTN000316458 is found in intracellular membrane-bounded organelle (GO:0043231) 20140612: Eukaryota_PTN000316458 is found in membrane-bounded vesicle (GO:0031988) # biological_process 20140612: Eukaryota_PTN000316458 participates in vesicle-mediated transport (GO:0016192) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Yeast is not in the tree. The yeast protein is involved is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis in complex with MON1. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).