# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function

# cellular_component
20140612: Eukaryota_PTN000315021 is found in endomembrane system (GO:0012505) 
20140612: Fungi_PTN000989606 is found in fungal-type vacuole membrane (GO:0000329) 
20140612: Fungi_PTN000989606 is found in Mon1-Ccz1 complex (GO:0035658) 

# biological_process
20140612: Eukaryota_PTN000315021 participates in vesicle-mediated transport (GO:0016192) 
20140612: Fungi_PTN000989606 participates in protein targeting to vacuole (GO:0006623) 
20140612: Euteleostomi_PTN000315049 participates in protein secretion (GO:0009306) 
20140612: Ecdysozoa_PTN000315081 participates in endosome to lysosome transport via multivesicular body sorting pathway (GO:0032510) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
MAF: In fungi, involved in multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
In Mouse (mammals ?), plays a role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).