# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20150706: Eukaryota_PTN000314659 contributes to function first spliceosomal transesterification activity (GO:0000384) 

# cellular_component
20150706: Eukaryota_PTN000314659 is found in post-mRNA release spliceosomal complex (GO:0071014) 
20150706: Eukaryota_PTN000314659 is found in post-spliceosomal complex (GO:0071020) 
20150706: Eukaryota_PTN000314659 is found in catalytic step 1 spliceosome (GO:0071012) 
20150706: Eukaryota_PTN000314659 is found in catalytic step 2 spliceosome (GO:0071013) 
20150706: Eukaryota_PTN000314659 is found in Prp19 complex (GO:0000974) 

# biological_process
20150706: Eukaryota_PTN000314659 participates in mRNA 3'-splice site recognition (GO:0000389) 
20150706: Eukaryota_PTN000314659 participates in generation of catalytic spliceosome for second transesterification step (GO:0000350) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains ISY1, which has been well characterized in S. cerevisiae as being a member of the PRP19 complex which is involved in assembly of the spliceosome, subsequent rearrangements to produce catalyticly active forms, and disassembly.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).