# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20150914: Eukaryota_PTN000313715 contributes to function second spliceosomal transesterification activity (GO:0000386) 

# cellular_component
20150914: Eukaryota_PTN000313715 is found in U2-type post-spliceosomal complex (GO:0071021) 
20150914: Eukaryota_PTN000313715 is found in U5 snRNP (GO:0005682) 
20150914: Eukaryota_PTN000313715 is found in U4/U6 x U5 tri-snRNP complex (GO:0046540) 

# biological_process
20150914: Eukaryota_PTN000313715 participates in nuclear retention of unspliced pre-mRNA at the site of transcription (GO:0071048) 
20150914: Eukaryota_PTN000313715 participates in generation of catalytic spliceosome for second transesterification step (GO:0000350) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains the PRP18 gene that is part of the U5 snRNP and that is involved in assembly of the tri-snRNP complex and remains present in the catalytic spliceosome, being involved in the conformational change to generate the catalytic spliceosome for the second transesterification step.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).