# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151202: Eukaryota_PTN000311158 has function inositol hexakisphosphate binding (GO:0000822) 20151202: Eukaryota_PTN000311158 has function translation initiation factor binding (GO:0031369) 20151202: Eukaryota_PTN000311158 has function phospholipid binding (GO:0005543) # cellular_component 20151202: Eukaryota_PTN000311158 is found in nuclear pore cytoplasmic filaments (GO:0044614) 20151202: Eukaryota_PTN000311158 is found in cytoplasm (GO:0005737) # biological_process 20151202: Eukaryota_PTN000311158 participates in regulation of translational initiation (GO:0006446) 20151202: Eukaryota_PTN000311158 participates in regulation of translational termination (GO:0006449) 20151202: Eukaryota_PTN000311158 participates in mRNA export from nucleus (GO:0006406) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family comprises the GLE1 protein, a conserved mRNA export factor associated with the cytoplasmic side of the nuclear pore complex (NPC) and involved in regulation of translational initiation and termination. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).