# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140724: Eumetazoa_PTN000984717 has function SMAD binding (GO:0046332) 

# cellular_component
20140724: Fungi_PTN001402448 is found in CORVET complex (GO:0033263) 
20140724: Fungi_PTN000984773 is found in fungal-type vacuole membrane (GO:0000329) 
20140724: Opisthokonta_PTN000984757 is found in lysosomal membrane (GO:0005765) 

# biological_process
20140724: Fungi_PTN001402448 participates in vacuolar acidification (GO:0007035) 
20140724: Fungi_PTN001402448 participates in protein targeting to vacuole (GO:0006623) 
20140724: Fungi_PTN001402448 participates in vacuole inheritance (GO:0000011) 
20140724: Eumetazoa_PTN000984717 participates in signal transduction (GO:0007165) 
20140724: Opisthokonta_PTN000307050 participates in vesicle-mediated transport (GO:0016192) 
20140724: Fungi_PTN000984773 participates in vacuole fusion, non-autophagic (GO:0042144) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).