# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150709: Eukaryota_PTN001767892 has function RNA polymerase II transcription cofactor activity (GO:0001104) 20150707: Tetrapoda_PTN000306229 has function thyroid hormone receptor binding (GO:0046966) 20150707: Tetrapoda_PTN000306229 has function retinoic acid receptor binding (GO:0042974) 20150707: Tetrapoda_PTN000306229 has function vitamin D receptor binding (GO:0042809) 20150707: Tetrapoda_PTN000306229 has function thyroid hormone receptor coactivator activity (GO:0030375) # cellular_component 20150709: Eukaryota_PTN001767892 is found in mediator complex (GO:0016592) # biological_process 20150709: Tetrapoda_PTN000306229 participates in cellular response to thyroid hormone stimulus (GO:0097067) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).