# HISTORY
08 May 2016: Updated by: TOUCHUP-v1.19
29 Apr 2016: Saved by krc using Paint 2.0-beta17
25 Apr 2016: Saved by krc using Paint 2.0-beta14
07 May 2016: Updated by: TOUCHUP-v1.18

# molecular_function
20150428: root_PTN000304594 has function U3 snoRNA binding (GO:0034511) 
20150428: root_PTN000304594 has function GTP binding (GO:0005525) 
20150428: root_PTN000304594 has function GTPase activity (GO:0003924) 

# cellular_component
20160425: Eukaryota_PTN000304595 is found in 90S preribosome (GO:0030686) 
20160425: Eukaryota_PTN000304671 is found in preribosome, small subunit precursor (GO:0030688) 

# biological_process
20150428: root_PTN000304594 participates in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000462) 
20150428: root_PTN000304594 participates in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000479) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains two proteins that are both involved in rRNA processing within the precursor of the ribosome to produce the mature SSU rRNA. Although the family has a duplication node at the top, this is probably OK as according to the UniProt pages for S. cerevisiae BMS1 and TSR1, both proteins are in the Bms1-like GTPase family within the TRAFAC class translation factor GTPase superfamily. Note though that BMS1 is included in two reviews of the Small Subunit (SSU) processome which is an early complex involved in processing the primary ribosomal transcript into ribosomal subunits and which specifically affects formation of the small subunit. TSR1, on the other hand, is not included in either of these reviews, though experimental data in S. cerevisiae has identified it is being part of the "preribosome, small subunit precursor".
- Phipps et al. 2011. The small subunit processome in ribosome biogenesis—progress and prospects (PMID:21318072)
- Feng et al. 2013. Origin and Evolution of the Eukaryotic SSU Processome Revealed by a Comprehensive Genomic Analysis and Implications for the Origin of the Nucleolus (PMID:24214024)

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).