# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150313: Eukaryota_PTN000300315 has function S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) 20150313: Fungi_PTN000980290 has function rRNA (adenine) methyltransferase activity (GO:0016433) 20150313: Opisthokonta_PTN000980278 has function methylated histone binding (GO:0035064) # cellular_component 20150313: Eukaryota_PTN000300315 is found in nucleolus (GO:0005730) 20150313: Opisthokonta_PTN000980278 is found in rDNA heterochromatin (GO:0033553) 20150313: Opisthokonta_PTN000980278 is found in chromatin silencing complex (GO:0005677) # biological_process 20150313: Fungi_PTN000980290 participates in ribosomal large subunit biogenesis (GO:0042273) 20150313: Fungi_PTN000980290 participates in rRNA methylation (GO:0031167) 20150313: Opisthokonta_PTN000980278 participates in cellular response to glucose starvation (GO:0042149) 20150313: Opisthokonta_PTN000980278 participates in chromatin silencing at rDNA (GO:0000183) 20150313: Opisthokonta_PTN000980278 participates in regulation of transcription by glucose (GO:0046015) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Methyltransferase that, according to litterature, seems to have distinct functions in fungi and animals. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).