# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141212: root_PTN000299690 has function solute:proton symporter activity (GO:0015295) 20141212: Eukaryota_PTN000299691 has function acetyl-CoA transporter activity (GO:0008521) # cellular_component 20141212: root_PTN000299690 is found in endoplasmic reticulum membrane (GO:0005789) 20141212: root_PTN000299690 is found in integral component of plasma membrane (GO:0005887) 20141212: Bacteria _PTN000299781 is NOT found in endoplasmic reticulum membrane (GO:0005789) # biological_process 20141212: root_PTN000299690 participates in transport (GO:0006810) 20141212: Bacteria _PTN000299781 participates in peptidoglycan transport (GO:0015835) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).