# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20150709: Eukaryota_PTN000299609 is found in precatalytic spliceosome (GO:0071011) 20150709: Eukaryota_PTN000299609 is found in U2 snRNP (GO:0005686) 20150709: Eukaryota_PTN000299609 is found in catalytic step 2 spliceosome (GO:0071013) 20150709: Eukaryota_PTN000299609 is found in U5 snRNP (GO:0005682) 20150709: Eukaryota_PTN000299609 is found in U1 snRNP (GO:0005685) 20150709: Eukaryota_PTN000299609 is found in U4/U6 x U5 tri-snRNP complex (GO:0046540) # biological_process 20150709: Eukaryota_PTN000299609 participates in spliceosomal snRNP assembly (GO:0000387) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains the highly conserved core Sm protein Sm D2 (encoded by SMD2 in S. cerevisiae and SNRPD2 in vertebrates). It is part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that are essential components of the spliceosomal U1, U2, U4, and U5 snRNPs. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).