# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141217: Tetrapoda_PTN000298409 has function cysteine-type endopeptidase inhibitor activity involved in apoptotic process (GO:0043027) # cellular_component 20141217: Opisthokonta_PTN000979111 is found in cytoplasm (GO:0005737) # biological_process 20141217: Euteleostomi_PTN000298384 participates in negative regulation of T cell activation (GO:0050868) 20141217: Euteleostomi_PTN000298384 participates in negative regulation of inflammatory response (GO:0050728) 20141217: Amniota_PTN000298430 participates in negative regulation of TOR signaling (GO:0032007) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).