# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160502: Eukaryota_PTN000297471 has function DNA replication origin binding (GO:0003688) # cellular_component 20160502: Eukaryota_PTN000297471 is found in nuclear origin of replication recognition complex (GO:0005664) 20160502: Eukaryota_PTN000297471 is found in nuclear pre-replicative complex (GO:0005656) 20160502: Eukaryota_PTN000297471 is found in nuclear chromosome, telomeric region (GO:0000784) 20160502: Eukaryota_PTN000297471 is found in DNA replication preinitiation complex (GO:0031261) # biological_process 20160502: Eukaryota_PTN000297471 participates in pre-replicative complex assembly involved in nuclear cell cycle DNA replication (GO:0006267) 20160502: Eukaryota_PTN000297471 participates in DNA replication initiation (GO:0006270) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).