# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140505: Opisthokonta_PTN000296496 contributes to function proton-transporting ATP synthase activity, rotational mechanism (GO:0046933) 

# cellular_component
20110106: Opisthokonta_PTN000296496 is found in mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) (GO:0000276) 

# biological_process
20110106: Opisthokonta_PTN000296496 participates in ATP synthesis coupled proton transport (GO:0015986) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
.
Phylogeny
There is one clade spanning fungi to humans, with no major duplications.  I would have expected a bacterial outgroup.  The fungal clade has descriptions of "ATP synthase subunit 4," while the metazoan proteins have descriptions of "ATP synthase subunit b."  Both are described as mitochondrial.
MF
-Ignore "protein binding."
-There are 3 remaining annotations: 2 to GO:0016887 "ATPase activity" (human and yeast), and 1 to GO:0046933 "hydrogen ion transporting ATP synthase activity, rotational mechanism" (yeast).  (Actually, yeast has 2 of these.)  All have "contributes_to" modifiers.  Propagate 46933 to AN0 and try to add the "contributes_to" modifier.  Do not propagate 16887, which is not the in vivo role of the enzyme but rather a useful and traditional in vitro assay for determining activity of purified protein.
-***Note that the "contributes_to" modifier is not available.
CC
-Propagate GO:0000276 "mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)" to AN0.  This term is correct for all family members, as the definition is "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins" and these proteins are all in F(o).  This covers all remaining mitochondrial terms.
-Ignore the HTP annotation to "lipid particle."
-Do not propagate the "cilium" annotation, which may be specific to one type of cells in worm.  See PMID 15563610.
BP
-Propagate GO:0015986 "ATP synthesis coupled proton transport" to AN0.
-Ignore the fly "phagocytosis" annotation which was really an experiment in Candida (PMID 16336044).
-All remaining annotations are HTP worm RNAi IMP's for developmental processes.  If correct, they are still too far downstream to consider for propagation.
MSL 6 Jan 2011
HM, reviewed 2014 May 5

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).