# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141212: Eumetazoa_PTN000976222 contributes to function histone-lysine N-methyltransferase activity (GO:0018024) 20141212: Eumetazoa_PTN000976222 has function chromatin binding (GO:0003682) 20141212: Eumetazoa_PTN000976222 has function Y-form DNA binding (GO:0000403) 20141212: Eumetazoa_PTN000976222 has function transcription regulatory region DNA binding (GO:0044212) 20141212: Eumetazoa_PTN000976222 has function double-stranded DNA binding (GO:0003690) # cellular_component 20141212: Eumetazoa_PTN000976222 is found in histone methyltransferase complex (GO:0035097) 20141212: Eumetazoa_PTN000976222 is found in chromatin (GO:0000785) # biological_process 20141212: Eumetazoa_PTN000976222 participates in histone lysine methylation (GO:0034968) 20141212: Eumetazoa_PTN000976222 participates in regulation of transcription from RNA polymerase II promoter (GO:0006357) 20141212: Eumetazoa_PTN000976222 participates in negative regulation of cell cycle (GO:0045786) 20141212: Eumetazoa_PTN000976222 participates in negative regulation of cell proliferation (GO:0008285) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Component of histone methyl transferase complex, regulates transcription both positively and negatively. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).