# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141112: Eukaryota_PTN000291965 has function GTPase activator activity (GO:0005096) 20141112: Eukaryota_PTN000291965 has function beta-tubulin binding (GO:0048487) # cellular_component 20141112: Eukaryota_PTN000291965 is found in microtubule (GO:0005874) 20141112: Opisthokonta_PTN000974682 is found in adherens junction (GO:0005912) 20141112: Opisthokonta_PTN000974682 is found in lateral plasma membrane (GO:0016328) 20141112: Opisthokonta_PTN000974682 is found in bicellular tight junction (GO:0005923) # biological_process 20141112: Eukaryota_PTN000291965 participates in tubulin complex assembly (GO:0007021) 20141112: Eukaryota_PTN000291965 participates in protein folding (GO:0006457) 20141112: Eukaryota_PTN000291965 participates in microtubule cytoskeleton organization (GO:0000226) 20141112: Eukaryota_PTN000291965 participates in positive regulation of GTPase activity (GO:0043547) 20141112: Opisthokonta_PTN000974682 participates in bicellular tight junction assembly (GO:0070830) 20141112: Opisthokonta_PTN000974682 participates in adherens junction assembly (GO:0034333) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).