# HISTORY 09 Aug 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20160809: Opisthokonta_PTN000966452 has function receptor binding (GO:0005102) # cellular_component 20160809: Eukaryota_PTN000278400 is found in cytoplasm (GO:0005737) 20160809: Opisthokonta_PTN000966452 is found in endoplasmic reticulum (GO:0005783) # biological_process 20160809: Opisthokonta_PTN000966452 participates in protein retention in ER lumen (GO:0006621) 20160809: Opisthokonta_PTN000966452 participates in regulation of receptor biosynthetic process (GO:0010869) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).