# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 15 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150807: root_PTN000271979 has function mRNA binding (GO:0003729) # cellular_component 20150807: root_PTN000271979 is found in U2-type prespliceosome (GO:0071004) 20150807: root_PTN000271979 is found in U1 snRNP (GO:0005685) # biological_process 20150807: root_PTN000271979 participates in mRNA splice site selection (GO:0006376) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains the LUC7 subunit of the U1 snRNP. The U1 snRNP is one the first snRNP to assemble onto the pre-mRNA, recognizing the 5' splice site (Wahl et al. 2009 PMID:19239890). While there is only a single LUC7 gene in the fungi, there are multiple LUC7-like genes in vertebrates: LUC7L, LUC7L2, & LUC7L3. Based on work in human, it appears that these are all associated with U1 snRNP and the major spliceosome and are probably involved in regulation of alternative splicing via recognition of the 5' splice site (Gao et al. 2011, PMID:21859973; Gao et al. 2012, PMID:22939879). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).