# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140829: Eukaryota_PTN000269659 contributes to function histone deacetylase activity (GO:0004407) 20140829: Eukaryota_PTN000269659 has function RNA polymerase II transcription corepressor activity (GO:0001106) # cellular_component 20140829: Eukaryota_PTN000269659 is found in histone deacetylase complex (GO:0000118) 20140829: Eukaryota_PTN000269659 is found in chromatin (GO:0000785) 20140829: Fungi_PTN000961035 is found in Rpd3S complex (GO:0032221) 20140829: Opisthokonta_PTN000961018 is found in Sin3 complex (GO:0016580) # biological_process 20140829: Eukaryota_PTN000269659 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 20140829: Eukaryota_PTN000269659 participates in histone deacetylation (GO:0016575) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: histone deacetylase complexes seem to have different names in mammals and fungi. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).