# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function

# cellular_component
20131114: Chordata_PTN000959606 is found in lipid particle (GO:0005811) 
20131114: Euteleostomi_PTN000267118 is found in nuclear chromatin (GO:0000790) 
20131114: Euteleostomi_PTN000267118 is NOT found in lipid particle (GO:0005811) 

# biological_process
20131114: Eumetazoa_PTN000959605 participates in regulation of apoptotic process (GO:0042981) 
20131114: Euteleostomi_PTN000267118 participates in negative regulation of execution phase of apoptosis (GO:1900118) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
trying to resolve the relationship between cidea, cideb, cidec, and dffa (syn dff45, icad): dffa negatively regulates dna fragmentation by forming a dimer with dffb (dff40). dffa is cleaved by caspase 3 (pmid:10713148), which releases dffb from the complex. dffb then has double-stranded endodeoxyribonuclease activity, thus, dffa negatively regulates the activity of dffb. review 2009 pmid: 18810317. review 2011 pmid:20967381. new go term requested using termgenie: go:1990238.  when the new term is available, needs to be propagated to the node of the parent of dffa.
For localization to the cytosol for DFFA, the evidence is too weak and we do not feel confident in propagating the term. http://www.proteinatlas.org/ENSG00000160049/subcellular
Initially, ectopic expression of CIDEA, CIDEB or CIDEC proteins was found to co-localize with mitochondria specific marker (mitotracker), suggesting these localize to the mitochondria. This localization pattern is likely due to the later stage of apoptosis. Recent studies have demonstrated that CIDE proteins localize to lipid droplets (LDs) and endoplasmic reticulum (ER) but not mitochondria. For this reason, we did not propagate the localization to mitochondrion nor to mitochondrial envelope.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).