# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141217: Eukaryota_PTN000259143 has function RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 20141217: Eukaryota_PTN000259143 has function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078) 20141217: Euteleostomi_PTN000259148 has LOST/MODIFIED function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078) # cellular_component 20141217: Eukaryota_PTN000259143 is found in nucleus (GO:0005634) # biological_process 20141217: Euteleostomi_PTN000259148 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).