# HISTORY 24 Nov 2016: Saved by mfeuerma using Paint 2.28 on 24 Nov 2016 using PANTHER version UPL 11.0 # molecular_function 20161124: Eukaryota_PTN000949730 has function ubiquitin protein ligase activity (GO:0061630) # cellular_component # biological_process 20161124: Eukaryota_PTN000949730 participates in Toll signaling pathway (GO:0008063) 20161124: Eukaryota_PTN000949730 participates in protein polyubiquitination (GO:0000209) 20161124: Euteleostomi_PTN000250515 participates in protein K48-linked ubiquitination (GO:0070936) 20161124: Euteleostomi_PTN002281052 participates in protein K63-linked ubiquitination (GO:0070534) 20161124: Eukaryota_PTN000949730 participates in immune response (GO:0006955) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).