# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20141119: Eukaryota_PTN000250001 is found in centrosome (GO:0005813) 20141119: Eukaryota_PTN000250001 is found in spindle (GO:0005819) 20141119: Viridiplantae_PTN000250045 is NOT found in centrosome (GO:0005813) # biological_process 20141119: Eukaryota_PTN000250001 participates in microtubule cytoskeleton organization (GO:0000226) 20141119: Eukaryota_PTN000250001 participates in cortical cytoskeleton organization (GO:0030865) 20141119: Opisthokonta_PTN000949378 participates in T cell homeostasis (GO:0043029) 20141119: Opisthokonta_PTN000949378 participates in positive regulation of B cell differentiation (GO:0045579) 20141119: Opisthokonta_PTN000949378 participates in B cell homeostasis (GO:0001782) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).