# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 15 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20131004: Eukaryota_PTN000248542 contributes to function RNA polymerase II activity (GO:0001055) 20131004: Eukaryota_PTN000248542 contributes to function RNA polymerase III activity (GO:0001056) 20131004: Eukaryota_PTN000248542 contributes to function RNA polymerase I activity (GO:0001054) # cellular_component 20131004: Eukaryota_PTN000248542 is found in DNA-directed RNA polymerase I complex (GO:0005736) 20131004: Eukaryota_PTN000248542 is found in DNA-directed RNA polymerase II, core complex (GO:0005665) 20131004: Eukaryota_PTN000248542 is found in DNA-directed RNA polymerase III complex (GO:0005666) # biological_process # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES this family comprises a conserved subunit of the multisubunit dna-dependent rna polymerases in eukaryotes. the p subunit of the archaeal multisubunit rna polymerases is considered homologous to this subunit (pmid:23768203); however the archaeal sequences are not present in this tree. this subunit is not present in the bacteria. Eukaryotic nuclear RNA polymerases ----------------------------- In the true eukaryotes, which have three conserved nuclear multisubunit RNA polymerases as well as two additional ones in plants, this is the family of the RPABC4 (aka RPB12, aka RPC10, aka POLR2K) subunit of the multisubunit DNA-directed RNA polymerases. In those eukaryotes which have only the three standard nuclear RNA polymerases (I, II, and III), this subunit is found in all three of these RNAPs (PMID:18573085). Within the plants, there are two additional nuclear RNA polymerases, RNAP IV and RNAP V, both derived from RNAP II (PMID:19110459). Annotation Comment ----------------- No direct propagations were made for BP terms since the appropriate terms can all be inferred by the Function-Process links from the propagated MF terms. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).