# HISTORY 16 Sep 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20160916: Euteleostomi_PTN000248354 has function receptor binding (GO:0005102) # cellular_component 20160916: Eukaryota_PTN000248323 is found in endosome (GO:0005768) # biological_process 20160916: Eukaryota_PTN000248323 participates in negative regulation of protein localization to cell surface (GO:2000009) 20160916: Eukaryota_PTN000248323 participates in late endosome to vacuole transport via multivesicular body sorting pathway (GO:0032511) 20160916: Euteleostomi_PTN000248354 participates in negative regulation of JAK-STAT cascade (GO:0046426) 20160916: Euteleostomi_PTN000248354 participates in negative regulation of growth hormone receptor signaling pathway (GO:0060400) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).