# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150717: root_PTN000247094 has function methyltransferase activity (GO:0008168) 20150717: root_PTN000247094 has function RNA binding (GO:0003723) 20150717: node_PTN000247326 has function tRNA (cytosine-2'-O-)-methyltransferase activity (GO:0052666) 20150717: node_PTN000247326 has function tRNA (uracil-2'-O-)-methyltransferase activity (GO:0052665) 20150717: node_PTN001738495 has function rRNA (guanosine-2'-O-)-methyltransferase activity (GO:0070039) 20150717: node_PTN000947837 has function tRNA (guanosine-2'-O-)-methyltransferase activity (GO:0009020) 20150717: Eukaryota_PTN000247165 has function tRNA (guanine) methyltransferase activity (GO:0016423) # cellular_component 20150717: node_PTN000247326 is found in cytosol (GO:0005829) 20150717: Eukaryota_PTN000247237 is found in mitochondrion (GO:0005739) 20150717: Bacteria _PTN000247285 is found in cytosol (GO:0005829) 20150717: Opisthokonta_PTN001738606 is found in mitochondrion (GO:0005739) # biological_process 20150717: root_PTN000247094 participates in RNA methylation (GO:0001510) 20150717: node_PTN000247326 participates in tRNA nucleoside ribose methylation (GO:0002128) 20150717: node_PTN000247303 participates in wobble position cytosine ribose methylation (GO:0002131) 20150717: node_PTN000247303 participates in wobble position uridine ribose methylation (GO:0002132) 20150717: node_PTN001738495 participates in enzyme-directed rRNA 2'-O-methylation (GO:0000453) 20150717: node_PTN000947837 participates in tRNA guanine ribose methylation (GO:0002938) 20150717: Eukaryota_PTN000247165 participates in tRNA methylation (GO:0030488) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).