# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140728: root_PTN000239344 has function methionine adenosyltransferase activity (GO:0004478) # cellular_component 20140728: root_PTN000239344 is found in cytosol (GO:0005829) 20140728: Euteleostomi_PTN000239379 is found in methionine adenosyltransferase complex (GO:0048269) # biological_process # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Family MF One annotated MF, clearly ancestral due to phylogenetic distribution Did not propagate other annotations because do not provide additional information CC Cytosolic ancestrally, gain of complex formation in MAT2A clade in vertebrates based on wikipedia BP Did not propagate anything, need an annotation to 0033353 S-adenosylmethionine cycle Specifically did not propagate processes covered by MF # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).