# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150320: node_PTN000237128 has function uridylyltransferase activity (GO:0070569) 20150320: Eukaryota_PTN000237224 has function UDP-N-acetylglucosamine diphosphorylase activity (GO:0003977) 20150320: Magnoliophyta_PTN001379022 has LOST/MODIFIED function UDP-N-acetylglucosamine diphosphorylase activity (GO:0003977) 20150320: node_PTN000237310 has LOST/MODIFIED function UDP-N-acetylglucosamine diphosphorylase activity (GO:0003977) # cellular_component 20150320: node_PTN000237128 is found in cytosol (GO:0005829) # biological_process 20150320: Eukaryota_PTN000237224 participates in UDP-N-acetylglucosamine biosynthetic process (GO:0006048) 20150320: Eukaryota_PTN000237212 participates in nucleotide-sugar biosynthetic process (GO:0009226) 20150320: Magnoliophyta_PTN001379022 does NOT participate in UDP-N-acetylglucosamine biosynthetic process (GO:0006048) 20150320: node_PTN000237310 does NOT participate in UDP-N-acetylglucosamine biosynthetic process (GO:0006048) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MF: based on the alignment and residues binding UDP-GlcNAc (pmid:17392279), there are 2 separate groups in this family: PTN000237129 (diverged from the residues needed for UDP-GlcNAc) and PTN000237210 (this conforms to the reqd residues). Within PTN000237210 PTN000237212 is somewhat less conserved. There are also other small clades in PTN000237210 that are divergent: PTN001379017, PTN000237310 and PTN001379022 - these should be excluded from any propagation. CC: all 3 subgroups have annotations to cytosol, so cytosoll was propagated to root. BP: based on the MF propagation. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).