# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
15 Mar 2016: Updated by: TOUCHUP-v1.14
25 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150724: root_PTN000228924 has function adenylate cyclase activity (GO:0004016) 
20150724: Tetrapoda_PTN000229610 has function G-protein coupled peptide receptor activity (GO:0008528) 
20150724: Tetrapoda_PTN000229610 has function natriuretic peptide receptor activity (GO:0016941) 
20150724: Eukaryota_PTN001728590 has function guanylate cyclase activity (GO:0004383) 
20150724: Eukaryota_PTN001376309 has function guanylate cyclase activity (GO:0004383) 
20150724: Eukaryota_PTN000229249 has function guanylate cyclase activity (GO:0004383) 
20150724: Euteleostomi_PTN001376517 has function natriuretic peptide receptor activity (GO:0016941) 
20150724: node_PTN001728738 has function guanylate cyclase activity (GO:0004383) 
20150724: Eukaryota_PTN001728590 has LOST/MODIFIED function adenylate cyclase activity (GO:0004016) 
20150724: Tetrapoda_PTN000229610 has LOST/MODIFIED function adenylate cyclase activity (GO:0004016) 
20150724: Eukaryota_PTN001376309 has LOST/MODIFIED function adenylate cyclase activity (GO:0004016) 
20150724: node_PTN001728738 has LOST/MODIFIED function adenylate cyclase activity (GO:0004016) 
20150724: Eukaryota_PTN000229249 has LOST/MODIFIED function adenylate cyclase activity (GO:0004016) 

# cellular_component
20150724: root_PTN000228924 is found in plasma membrane (GO:0005886) 
20150724: Eukaryota_PTN001728590 is found in guanylate cyclase complex, soluble (GO:0008074) 
20150724: Eukaryota_PTN001376309 is found in guanylate cyclase complex, soluble (GO:0008074) 
20150724: Eukaryota_PTN000229249 is found in guanylate cyclase complex, soluble (GO:0008074) 

# biological_process
20150724: root_PTN000228924 participates in cyclic nucleotide biosynthetic process (GO:0009190) 
20150724: root_PTN000228924 participates in signal transduction (GO:0007165) 
20150724: Eukaryota_PTN001728527 participates in cAMP biosynthetic process (GO:0006171) 
20150724: Eukaryota_PTN001728527 participates in adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193) 
20150724: Eukaryota_PTN001728527 participates in cAMP-mediated signaling (GO:0019933) 
20150724: Eukaryota_PTN001728527 participates in adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) 
20150724: Eukaryota_PTN000229249 participates in cGMP biosynthetic process (GO:0006182) 
20150724: node_PTN000937789 participates in receptor guanylyl cyclase signaling pathway (GO:0007168) 
20150724: Euteleostomi_PTN001376517 participates in receptor guanylyl cyclase signaling pathway (GO:0007168) 
20150724: node_PTN001728738 participates in cGMP biosynthetic process (GO:0006182) 
20150724: node_PTN000747158 participates in cAMP biosynthetic process (GO:0006171) 
20150724: Tetrapoda_PTN000229610 does NOT participate in cAMP biosynthetic process (GO:0006171) 
20150724: Tetrapoda_PTN000229610 does NOT participate in cyclic nucleotide biosynthetic process (GO:0009190) 
20150724: Tetrapoda_PTN000229610 does NOT participate in adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains both adenylate and guanylate cyclase. The tree is a bit auckward. The two devides well, except for the bacterial sequences at the bottom. Thus, it is possible that AC evolved earlier, and GC came later.
There are many Reactome annotations that are not used for propagation.
24 July 2015, HM

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).