# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 15 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150624: root_PTN000228708 has function 4 iron, 4 sulfur cluster binding (GO:0051539) 20150624: root_PTN000228708 has function methylthiotransferase activity (GO:0035596) 20150624: Eukaryota_PTN000228777 has function protein kinase regulator activity (GO:0019887) 20150624: Bacteria _PTN000228824 has function N6-isopentenyladenosine methylthiotransferase activity (GO:0035597) 20150624: node_PTN000228840 has function aspartic acid methylthiotransferase activity (GO:0035599) 20150624: node_PTN000228709 has function N6-threonylcarbomyladenosine methylthiotransferase activity (GO:0035598) 20150624: Eukaryota_PTN000228777 has LOST/MODIFIED function 4 iron, 4 sulfur cluster binding (GO:0051539) 20150624: Eukaryota_PTN000228777 has LOST/MODIFIED function methylthiotransferase activity (GO:0035596) # cellular_component 20150624: node_PTN000228861 is found in cytosol (GO:0005829) 20150624: node_PTN000228840 is found in cytosol (GO:0005829) 20150624: Eukaryota_PTN000228711 is found in endoplasmic reticulum (GO:0005783) # biological_process 20150624: root_PTN000228708 participates in tRNA methylthiolation (GO:0035600) 20150624: Eukaryota_PTN000228777 participates in regulation of protein kinase activity (GO:0045859) 20150624: Eukaryota_PTN000228777 does NOT participate in tRNA methylthiolation (GO:0035600) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).