# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
15 Mar 2016: Updated by: TOUCHUP-v1.14
25 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20140825: root_PTN000225966 has function protein serine/threonine kinase activity (GO:0004674) 

# cellular_component
20140825: root_PTN000225966 is found in cytoplasm (GO:0005737) 
20140825: root_PTN000225966 is found in nucleus (GO:0005634) 

# biological_process
20140825: root_PTN000225966 participates in regulation of cell shape (GO:0008360) 
20140825: root_PTN000225966 participates in peptidyl-serine phosphorylation (GO:0018105) 
20140825: Eukaryota_PTN000226268 participates in Wnt signaling pathway (GO:0016055) 
20140825: Eukaryota_PTN000226268 participates in endocytosis (GO:0006897) 
20140825: Eukaryota_PTN000225967 participates in Wnt signaling pathway (GO:0016055) 
20140825: Eukaryota_PTN000225967 participates in phagocytosis (GO:0006909) 
20140825: Eukaryota_PTN000747050 participates in double-strand break repair via break-induced replication (GO:0000727) 
20140825: Eukaryota_PTN000747050 participates in phagocytosis (GO:0006909) 
20140825: Eukaryota_PTN000747050 participates in DNA replication initiation (GO:0006270) 
# PRUNED

07 May 2016: node_PTN000935933 has been pruned from tree

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
25 Mar 2016: node_PTN000935933 has been pruned from tree
15 Mar 2016: node_PTN000935933 has been pruned from tree
Cdc7 is a Serine/threonine-protein kinase. It is required for both initiation of DNA replication and post-replication repair (PRR), and it is also required for Break-Induced Replication (BIR). BIR is an efficient homologous recombination (HR) pathway employed to repair a DNA double-strand break (DSB) when homology is restricted to one end. Cdc 7 is needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression.
Decided to propagate Cdc7's involvement in double-strand break repair via break-induced replication throughout Eukaryote_PTN0007477050 only, because none of the other casein kinases have any evidence in support of their involvement in the process.
The reason for pruning the purple sea urchin clade (Strongylocentrotus purpuratus) is that these entries no longer exist in UniProt.
There was not sufficient experimental evidence to extend Wnt Signaling Pathway (GO:0016055) to the root of the tree. Neither cdc7 nor TTBK1/2 had evidence in support of their participation on WntSP. Chose to only propagate to those clades with sufficient supporting evidence. This left a few clades of nematodes out of the propagation due to the phylogenetic distance estimated via seq. alignment results.
Not sufficient evidence to know whether TTBK1/2 are involved in endocytosis and phagocytosis either, so did not propagate to those groups.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).