# HISTORY 03 Jun 2016: Saved by pascalegaudet using Paint 2.0-beta19 02 Jun 2016: Saved by pascalegaudet using Paint 2.0-beta19 # molecular_function 20160601: Metazoa_PTN001724962 has function G-protein coupled receptor activity (GO:0004930) 20160601: Euteleostomi_PTN000221595 has function prostacyclin receptor activity (GO:0016501) 20160601: Tetrapoda_PTN000933527 has function prostaglandin D receptor activity (GO:0004956) 20160601: Tetrapoda_PTN000221665 has function prostaglandin E receptor activity (GO:0004957) 20160601: Euteleostomi_PTN000221616 has function thromboxane A2 receptor activity (GO:0004961) 20160601: Euteleostomi_PTN000221689 has function prostaglandin E receptor activity (GO:0004957) 20160601: Euteleostomi_PTN000221641 has function prostaglandin F receptor activity (GO:0004958) 20160601: Euteleostomi_PTN000221704 has function prostaglandin E receptor activity (GO:0004957) 20160601: Euteleostomi_PTN000221548 has function prostaglandin E receptor activity (GO:0004957) # cellular_component 20160601: Metazoa_PTN001724962 is found in integral component of plasma membrane (GO:0005887) # biological_process 20160601: Metazoa_PTN001724962 participates in inflammatory response (GO:0006954) 20160602: Metazoa_PTN001724962 participates in adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) 20160602: Metazoa_PTN001724962 participates in regulation of cytosolic calcium ion concentration (GO:0051480) 20160601: Euteleostomi_PTN000221595 participates in cellular response to prostaglandin D stimulus (GO:0071799) 20160601: Tetrapoda_PTN000933527 participates in positive regulation of vasodilation (GO:0045909) 20160602: Euteleostomi_PTN000221664 participates in phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) 20160601: Pancrustacea_PTN000933555 does NOT participate in inflammatory response (GO:0006954) 20160602: Metazoa_PTN001724962 participates in positive regulation of cytosolic calcium ion concentration (GO:0007204) 20160602: Euteleostomi_PTN000221664 participates in intestine smooth muscle contraction (GO:0014827) 20160602: Euteleostomi_PTN000221664 participates in negative regulation of gastric acid secretion (GO:0060455) 20160603: Euteleostomi_PTN000221616 participates in positive regulation of vasoconstriction (GO:0045907) 20160603: Euteleostomi_PTN000221616 participates in positive regulation of blood pressure (GO:0045777) 20160603: Tetrapoda_PTN000221705 participates in cellular response to prostaglandin E stimulus (GO:0071380) 20160603: Euteleostomi_PTN000221548 participates in cellular response to prostaglandin E stimulus (GO:0071380) 20160602: Tetrapoda_PTN000933527 does NOT participate in adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) 20160602: Euteleostomi_PTN000221664 does NOT participate in adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Review: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/ Also used wikipedia and UniProtKB to decide which annotations to propagate, since there is litte consistency between the annotations in different species. PG 2016-06-03 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).