# HISTORY 28 Jul 2016: Saved by mfeuerma using Paint 2.21 # molecular_function 20160728: Eukaryota_PTN000221191 has function C-5 sterol desaturase activity (GO:0000248) 20160728: Eukaryota_PTN000221246 has function C-4 methylsterol oxidase activity (GO:0000254) 20160728: Eukaryota_PTN000221170 has function sphingosine hydroxylase activity (GO:0000170) 20160728: root_PTN000221168 has function oxidoreductase activity (GO:0016491) 20160728: Eukaryota_PTN000221170 has function sphingolipid delta-4 desaturase activity (GO:0042284) 20160728: Deuterostomia_PTN000221316 has function steroid hydroxylase activity (GO:0008395) 20160728: Opisthokonta_PTN000933275 has function lathosterol oxidase activity (GO:0050046) # cellular_component 20160728: node_PTN000221169 is found in endoplasmic reticulum membrane (GO:0005789) 20160728: root_PTN000221168 is found in membrane (GO:0016020) # biological_process 20160728: Eukaryota_PTN000221191 participates in sterol biosynthetic process (GO:0016126) 20160728: Eukaryota_PTN000221246 participates in sterol biosynthetic process (GO:0016126) 20160728: Fungi_PTN000933288 participates in ergosterol biosynthetic process (GO:0006696) 20160728: Opisthokonta_PTN000933275 participates in cholesterol biosynthetic process via lathosterol (GO:0033490) 20160728: Fungi_PTN000933387 participates in ergosterol biosynthetic process (GO:0006696) 20160728: Deuterostomia_PTN000221316 participates in cholesterol metabolic process (GO:0008203) 20160728: Embryophyta_PTN000933437 participates in 4-alpha-methyl-delta7-sterol oxidation (GO:0080065) 20160728: root_PTN000221168 participates in lipid metabolic process (GO:0006629) 20160728: Eukaryota_PTN000221170 participates in sphingolipid biosynthetic process (GO:0030148) 20160728: Viridiplantae_PTN001724833 participates in wax biosynthetic process (GO:0010025) 20160728: Viridiplantae_PTN001724833 participates in alkane biosynthetic process (GO:0043447) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).