# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150604: root_PTN000220169 has function zinc ion binding (GO:0008270) 20150604: root_PTN000220169 has function metalloendopeptidase activity (GO:0004222) # cellular_component 20150604: Eukaryota_PTN000747147 is found in mitochondrial inner membrane (GO:0005743) 20150604: Eukaryota_PTN000220551 is found in mitochondrion (GO:0005739) 20150604: Deuterostomia_PTN000220589 is found in peroxisomal matrix (GO:0005782) 20150604: Deuterostomia_PTN000220589 is found in cytosol (GO:0005829) 20150604: Eukaryota_PTN000220240 is found in mitochondrial respiratory chain complex III (GO:0005750) 20150604: Eukaryota_PTN000220483 is found in mitochondrion (GO:0005739) # biological_process 20150604: root_PTN000220169 participates in protein processing (GO:0016485) 20150604: Eukaryota_PTN000747147 participates in protein processing involved in protein targeting to mitochondrion (GO:0006627) 20150604: Eukaryota_PTN000220551 participates in proteolysis involved in cellular protein catabolic process (GO:0051603) 20150604: Eukaryota_PTN000220551 participates in peptide catabolic process (GO:0043171) 20150604: Eukaryota_PTN000220240 participates in aerobic respiration (GO:0009060) 20150604: Eukaryota_PTN000220240 participates in mitochondrial electron transport, ubiquinol to cytochrome c (GO:0006122) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).