# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.14
25 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20140924: root_PTN000218063 has function cytokine activity (GO:0005125) 
20140924: root_PTN000218063 has function transforming growth factor beta receptor binding (GO:0005160) 
20140924: Deuterostomia_PTN000218722 has function type II transforming growth factor beta receptor binding (GO:0005114) 
20140924: Eumetazoa_PTN000932177 has function BMP receptor binding (GO:0070700) 
20140924: Euteleostomi_PTN000747027 has function BMP receptor binding (GO:0070700) 
20140924: Deuterostomia_PTN000218109 has function type I activin receptor binding (GO:0070698) 
20140924: Euteleostomi_PTN000218867 has function BMP receptor binding (GO:0070700) 

# cellular_component
20140924: root_PTN000218063 is found in extracellular space (GO:0005615) 

# biological_process
20140925: root_PTN000218063 participates in regulation of apoptotic process (GO:0042981) 
20140924: root_PTN000218063 participates in cell development (GO:0048468) 
20140924: root_PTN000218063 participates in positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862) 
20140925: root_PTN000218063 participates in SMAD protein signal transduction (GO:0060395) 
20140925: root_PTN000218063 participates in regulation of MAPK cascade (GO:0043408) 
20140924: Deuterostomia_PTN000218722 participates in transforming growth factor beta receptor signaling pathway (GO:0007179) 
20140925: Deuterostomia_PTN000218722 participates in regulation of cell proliferation (GO:0042127) 
20140924: Eumetazoa_PTN000932177 participates in BMP signaling pathway (GO:0030509) 
20140925: Euteleostomi_PTN000747027 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 
20140925: Euteleostomi_PTN000747027 participates in negative regulation of apoptotic process (GO:0043066) 
20140924: Bilateria_PTN000218210 participates in BMP signaling pathway (GO:0030509) 
20140925: Euteleostomi_PTN000218867 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
One issue with this family is how broadly TGF beta receptor signaling is referred. Some annotations consider that pathways signaled by all members of the TGF beta superfamily are TGF beta receptor signaling pathway, while others use more strictly rules, ie., only the pathways signaled through the TGF-beta receptors are considered TGF beta receptor signaling pathway. The progagtion is more based on the latter.
For BMP pathways, many are inferred through IMP annotations. They are not propagated.
All the development process annotations are not propagated.
The paint curation is not completed. Need someone else to take another look.
Sept. 24, 2014 - HM

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).