# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150717: Bacteria _PTN000202125 has function nucleoside-triphosphate diphosphatase activity (GO:0047429) 20150717: node_PTN000202148 has function S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) 20150717: node_PTN000202148 has function O-methyltransferase activity (GO:0008171) 20150717: Euteleostomi_PTN000202159 has function acetylserotonin O-methyltransferase activity (GO:0017096) # cellular_component 20150717: Embryophyta_PTN001714420 is found in cytosol (GO:0005829) # biological_process 20150717: node_PTN000202148 participates in aromatic compound biosynthetic process (GO:0019438) 20150717: Mammalia_PTN000202161 participates in melatonin biosynthetic process (GO:0030187) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED ## Annotations that have been removed. 20150717: root_PTN000202054 to metabolic process (GO:0008152) is an excluded term and not to be used for annotation # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).