# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20160119: Euteleostomi_PTN001711959 has function hormone activity (GO:0005179) 20160119: Euteleostomi_PTN001711959 has function peptide hormone receptor binding (GO:0051428) # cellular_component 20160119: Euteleostomi_PTN001711959 is found in extracellular space (GO:0005615) # biological_process 20160119: Euteleostomi_PTN001711959 participates in positive regulation of STAT protein import into nucleus (GO:2000366) 20160119: Euteleostomi_PTN001711959 participates in activation of protein kinase C activity (GO:1990051) 20160119: Euteleostomi_PTN001711959 participates in negative regulation of appetite by leptin-mediated signaling pathway (GO:0038108) 20160119: Euteleostomi_PTN001711959 participates in energy reserve metabolic process (GO:0006112) 20160119: Euteleostomi_PTN001711959 participates in positive regulation of p38MAPK cascade (GO:1900745) 20160119: Euteleostomi_PTN001711959 participates in response to insulin (GO:0032868) 20160119: Euteleostomi_PTN001711959 participates in positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068) 20160119: Euteleostomi_PTN001711959 participates in positive regulation of TOR signaling (GO:0032008) 20160119: Euteleostomi_PTN001711959 participates in lipid metabolic process (GO:0006629) 20160119: Euteleostomi_PTN001711959 participates in tyrosine phosphorylation of STAT protein (GO:0007260) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).