# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
14 Mar 2016: Updated by: TOUCHUP-v1.14
24 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150814: root_PTN000188395 has function ubiquitin protein ligase activity (GO:0061630) 
20150814: root_PTN000188395 has function ubiquitin conjugating enzyme binding (GO:0031624) 

# cellular_component
20150814: root_PTN000188395 is found in cytoplasm (GO:0005737) 
20150814: root_PTN000188395 is found in ubiquitin ligase complex (GO:0000151) 
20150814: Opisthokonta_PTN001706324 is found in nucleus (GO:0005634) 
20150814: Eukaryota_PTN001363322 is found in nucleus (GO:0005634) 
20150814: Metazoa_PTN001706610 is found in endoplasmic reticulum (GO:0005783) 
20150814: Metazoa_PTN001706610 is found in Golgi apparatus (GO:0005794) 
20150814: Metazoa_PTN001706610 is found in mitochondrion (GO:0005739) 
20150814: Metazoa_PTN001706610 is found in cytosol (GO:0005829) 
20150814: Euteleostomi_PTN000188673 is found in centrosome (GO:0005813) 
20150814: Euteleostomi_PTN000746126 is found in cytolytic granule (GO:0044194) 
20150814: Euteleostomi_PTN000188771 is found in Golgi apparatus (GO:0005794) 
20150814: Euteleostomi_PTN000188750 is found in mitochondrial membrane (GO:0031966) 

# biological_process
20150814: root_PTN000188395 participates in protein polyubiquitination (GO:0000209) 
20150814: root_PTN000188395 participates in protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787) 
20150814: root_PTN000188395 participates in positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436) 
20150814: Opisthokonta_PTN001706324 participates in signal transduction (GO:0007165) 
20150814: Fungi_PTN000913708 participates in histone ubiquitination (GO:0016574) 
20150814: Fungi_PTN000913708 participates in histone catabolic process (GO:0036205) 
20150814: Metazoa_PTN001706610 participates in multicellular organism development (GO:0007275) 
20150814: Metazoa_PTN001706610 participates in mitophagy (GO:0000422) 
20150814: Metazoa_PTN001706610 participates in regulation of cellular response to oxidative stress (GO:1900407) 
20150814: Metazoa_PTN001706610 participates in signal transduction (GO:0007165) 
20150814: Metazoa_PTN001706610 participates in regulation of mitochondrion organization (GO:0010821) 
20150814: Metazoa_PTN001706610 participates in negative regulation of protein phosphorylation (GO:0001933) 
20150814: Metazoa_PTN001706610 participates in regulation of apoptotic process (GO:0042981) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).