# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150507: node_PTN000177662 has function transporter activity (GO:0005215) 20150507: Tetrapoda_PTN000178180 has function L-proline transmembrane transporter activity (GO:0015193) 20150507: Chordata_PTN000907055 has function amino acid transmembrane transporter activity (GO:0015171) 20150507: Chordata_PTN000178147 has function glycine:sodium symporter activity (GO:0015375) 20150507: Eumetazoa_PTN000907005 has function amino acid transmembrane transporter activity (GO:0015171) 20150507: Euteleostomi_PTN000177810 has function proline:sodium symporter activity (GO:0005298) 20150507: Euteleostomi_PTN000177672 has function neutral amino acid transmembrane transporter activity (GO:0015175) 20150507: Chordata_PTN001359737 has function taurine:sodium symporter activity (GO:0005369) 20150507: Bilateria_PTN000178288 has function serotonin transmembrane transporter activity (GO:0015222) 20150507: Bilateria_PTN000746001 has function dopamine:sodium symporter activity (GO:0005330) 20150507: Euteleostomi_PTN000178409 has function norepinephrine transmembrane transporter activity (GO:0005333) 20150507: Bilateria_PTN000177868 has function gamma-aminobutyric acid:sodium symporter activity (GO:0005332) 20150507: Chordata_PTN001359718 has function creatine:sodium symporter activity (GO:0005309) 20150507: Euteleostomi_PTN000178409 has LOST/MODIFIED function dopamine:sodium symporter activity (GO:0005330) # cellular_component 20150507: node_PTN000177662 is found in integral component of plasma membrane (GO:0005887) 20150507: Bilateria_PTN000178288 is found in neuron projection (GO:0043005) 20150507: Bilateria_PTN000746001 is found in neuron projection (GO:0043005) 20150507: Bilateria_PTN000177868 is found in neuron projection (GO:0043005) # biological_process 20150507: node_PTN000177662 participates in transport (GO:0006810) 20150507: Chordata_PTN000907055 participates in cellular amino acid metabolic process (GO:0006520) 20150507: Chordata_PTN000178147 participates in synaptic transmission, glycinergic (GO:0060012) 20150507: Chordata_PTN000178147 participates in glycine import (GO:0036233) 20150507: Euteleostomi_PTN000177810 participates in leucine transport (GO:0015820) 20150507: Euteleostomi_PTN000177745 participates in leucine transport (GO:0015820) 20150507: Euteleostomi_PTN000177745 participates in glycine transport (GO:0015816) 20150507: Euteleostomi_PTN000177745 participates in proline transport (GO:0015824) 20150507: Euteleostomi_PTN000177745 participates in alanine transport (GO:0032328) 20150507: Chordata_PTN001359737 participates in taurine transport (GO:0015734) 20150507: Chordata_PTN001359737 participates in amino acid transmembrane transport (GO:0003333) 20150507: Bilateria_PTN000178288 participates in serotonin uptake (GO:0051610) 20150507: Bilateria_PTN000178288 participates in synaptic transmission (GO:0007268) 20150507: Bilateria_PTN000746001 participates in dopamine uptake involved in synaptic transmission (GO:0051583) 20150507: Euteleostomi_PTN000178409 participates in norepinephrine transport (GO:0015874) 20150507: Bilateria_PTN000177868 participates in neurotransmitter transport (GO:0006836) 20150507: Bilateria_PTN000177868 participates in gamma-aminobutyric acid transport (GO:0015812) 20150507: Bilateria_PTN000177868 participates in synaptic transmission (GO:0007268) 20150507: Euteleostomi_PTN000178409 does NOT participate in dopamine uptake involved in synaptic transmission (GO:0051583) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).