# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20110207: Eukaryota_PTN000177280 is found in mitochondrial respiratory chain complex I (GO:0005747) # biological_process # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MF Propagated GO:8137 NADH dehydrogenase (ubiquinone) activity to AN1. Annotations in the AN90 node were diverse and hence propagated the higher level term GO:16651, oxidoreductase activity, acting on NADH or NADPH. Similarly propagetd GO:16491, oidoreducatase activity to AN341 node. CC Propagated GO:5747 mitochondrial respiratory chain complex I to AN1. Propagated GO:16020, membrane to AN341 because some of the bacterial proteins are localized to plasma membrane or membrane. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).