# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 14 Mar 2016: Updated by: TOUCHUP-v1.14 24 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150312: Eukaryota_PTN000170807 has function adenosylmethionine decarboxylase activity (GO:0004014) 20150312: Mammalia_PTN000170816 has function putrescine binding (GO:0019810) 20150312: Trypanosomatidae_PTN000902589 has LOST/MODIFIED function adenosylmethionine decarboxylase activity (GO:0004014) # cellular_component 20150312: Eukaryota_PTN000170807 is found in cytosol (GO:0005829) # biological_process 20150312: Eukaryota_PTN000170807 participates in spermidine biosynthetic process (GO:0008295) 20150312: Eukaryota_PTN000170807 participates in spermine biosynthetic process (GO:0006597) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Function: exluded parasitic sequences that lack catalytic residues and are highly divergent. According to pmid:19997761 these are prozymes that activate the actual enzymes. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).