# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150909: root_PTN000169310 has function zinc ion transmembrane transporter activity (GO:0005385) 20150909: Euteleostomi_PTN000169447 has function calcium channel inhibitor activity (GO:0019855) 20150909: Magnoliophyta_PTN000169358 has function manganese:proton antiporter activity (GO:0010486) 20150909: Bacteria _PTN000169392 has function cadmium ion transmembrane transporter activity (GO:0015086) 20150909: Bacteria _PTN000169392 has function zinc efflux active transmembrane transporter activity (GO:0015341) 20150909: Bacteria _PTN000169392 has function ferrous iron transmembrane transporter activity (GO:0015093) # cellular_component 20150909: root_PTN000169310 is found in membrane (GO:0016020) 20150909: Eukaryota_PTN000169412 is found in Golgi apparatus (GO:0005794) 20150909: Fungi_PTN000901754 is found in fungal-type vacuole (GO:0000324) 20150909: Bilateria_PTN000169416 is found in plasma membrane (GO:0005886) 20150909: Euteleostomi_PTN000169447 is found in Golgi apparatus (GO:0005794) 20150909: Euteleostomi_PTN000169447 is found in endoplasmic reticulum (GO:0005783) 20150909: Bilateria_PTN000169638 is found in plasma membrane (GO:0005886) 20150909: Bilateria_PTN000169638 is found in cytoplasmic, membrane-bounded vesicle (GO:0016023) 20150909: Chordata_PTN000901675 is found in cytoplasmic, membrane-bounded vesicle (GO:0016023) 20150909: Chordata_PTN000901675 is found in late endosome (GO:0005770) 20150909: Viridiplantae_PTN000169769 is found in vacuole (GO:0005773) # biological_process 20150909: root_PTN000169310 participates in regulation of sequestering of zinc ion (GO:0061088) 20150909: root_PTN000169310 participates in response to zinc ion (GO:0010043) 20150909: Euteleostomi_PTN000169648 participates in response to glucose (GO:0009749) 20150909: Euteleostomi_PTN000169648 participates in insulin secretion (GO:0030073) 20150909: Bacteria _PTN000169392 participates in cadmium ion transmembrane transport (GO:0070574) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).