# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 07 May 2016: Updated by: TOUCHUP-v1.18 # molecular_function 20150319: root_PTN000165932 has function phenylalanine-tRNA ligase activity (GO:0004826) 20150319: Eukaryota_PTN000711660 has function rRNA (uridine-N3-)-methyltransferase activity (GO:0070042) 20150319: Eukaryota_PTN000711660 has LOST/MODIFIED function phenylalanine-tRNA ligase activity (GO:0004826) # cellular_component 20150319: root_PTN000165932 is found in cytoplasm (GO:0005737) 20150319: Eukaryota_PTN000165999 is found in mitochondrion (GO:0005739) 20150319: Eukaryota_PTN000165935 is found in phenylalanine-tRNA ligase complex (GO:0009328) # biological_process 20150319: root_PTN000165932 participates in phenylalanyl-tRNA aminoacylation (GO:0006432) 20150319: Eukaryota_PTN000711660 participates in rRNA base methylation (GO:0070475) 20150319: Eukaryota_PTN000711660 does NOT participate in phenylalanyl-tRNA aminoacylation (GO:0006432) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Neofunctioalization in the human ALG9/yeast BTM5 branch to rRNA editing, as sown by papers for the yeast BTM5 gene. Annotated PG 2015-03-19. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).