# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150424: node_PTN000164249 has function zinc ion binding (GO:0008270) 20150424: node_PTN000164249 has function metalloaminopeptidase activity (GO:0070006) 20150424: node_PTN000164249 has function peptide binding (GO:0042277) 20150424: Opisthokonta_PTN000164255 has function epoxide hydrolase activity (GO:0004301) 20150424: Deuterostomia_PTN000164329 has function leukotriene-A4 hydrolase activity (GO:0004463) # cellular_component 20150424: node_PTN000164249 is found in cytoplasm (GO:0005737) 20150424: Bacteria _PTN000164823 is found in plasma membrane (GO:0005886) 20150424: Euteleostomi_PTN000164305 is found in extracellular region (GO:0005576) 20150424: Euteleostomi_PTN000164305 is found in secretory granule (GO:0030141) 20150424: Deuterostomia_PTN000164329 is found in nucleus (GO:0005634) 20150424: Eumetazoa_PTN000898498 is found in nucleolus (GO:0005730) 20150424: Euteleostomi_PTN000164536 is found in endoplasmic reticulum lumen (GO:0005788) 20150424: Euteleostomi_PTN000164589 is found in endoplasmic reticulum lumen (GO:0005788) # biological_process 20150424: node_PTN000164249 participates in peptide catabolic process (GO:0043171) 20150424: node_PTN000164249 participates in proteolysis (GO:0006508) 20150424: Euteleostomi_PTN000164305 participates in negative regulation of blood pressure (GO:0045776) 20150424: Opisthokonta_PTN000164255 participates in cellular lipid metabolic process (GO:0044255) 20150424: Deuterostomia_PTN000164329 participates in leukotriene biosynthetic process (GO:0019370) 20150424: node_PTN000745637 participates in regulation of blood pressure (GO:0008217) 20150424: Euteleostomi_PTN000164536 participates in antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) 20150424: Euteleostomi_PTN000164589 participates in antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) 20150424: Euteleostomi_PTN000164564 participates in cell-cell signaling (GO:0007267) 20150424: Euteleostomi_PTN000164564 participates in signal transduction (GO:0007165) 20150424: Euteleostomi_PTN000164501 participates in signal transduction (GO:0007165) 20150424: Euteleostomi_PTN000164501 participates in cell-cell signaling (GO:0007267) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).