# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20151009: root_PTN000163972 has function serine-type carboxypeptidase activity (GO:0004185) 
20151009: root_PTN000163972 has function metallocarboxypeptidase activity (GO:0004181) 
20151009: Euteleostomi_PTN000164084 has LOST/MODIFIED function serine-type carboxypeptidase activity (GO:0004185) 
20151009: Euteleostomi_PTN000164084 has LOST/MODIFIED function metallocarboxypeptidase activity (GO:0004181) 
20151009: Euteleostomi_PTN000163981 has LOST/MODIFIED function serine-type carboxypeptidase activity (GO:0004185) 
20151009: Euteleostomi_PTN000163981 has LOST/MODIFIED function metallocarboxypeptidase activity (GO:0004181) 

# cellular_component
20151009: root_PTN000163972 is found in extracellular space (GO:0005615) 
20151009: Bilateria_PTN000164185 is found in plasma membrane (GO:0005886) 
20151009: Bilateria_PTN000164185 is found in cell surface (GO:0009986) 
20151009: Bilateria_PTN001693453 is found in secretory granule (GO:0030141) 
20151009: Bilateria_PTN001693453 is found in Golgi apparatus (GO:0005794) 
20151009: Bilateria_PTN001693453 is found in neuronal cell body (GO:0043025) 
20151009: Bilateria_PTN001693453 is found in synaptic membrane (GO:0097060) 
20151009: Eumetazoa_PTN001693477 is found in nucleus (GO:0005634) 
20151009: Eumetazoa_PTN001693477 is found in trans-Golgi network (GO:0005802) 

# biological_process
20151009: root_PTN000163972 participates in protein processing (GO:0016485) 
20151009: root_PTN000163972 participates in peptide metabolic process (GO:0006518) 
20151009: Bilateria_PTN001693453 participates in insulin processing (GO:0030070) 
20151009: Euteleostomi_PTN000164084 does NOT participate in protein processing (GO:0016485) 
20151009: Euteleostomi_PTN000164084 does NOT participate in peptide metabolic process (GO:0006518) 
20151009: Euteleostomi_PTN000163981 does NOT participate in protein processing (GO:0016485) 
20151009: Euteleostomi_PTN000163981 does NOT participate in peptide metabolic process (GO:0006518) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).