# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150305: node_PTN000157685 has function pyridoxal phosphate binding (GO:0030170) 20150305: node_PTN000157685 has function glycogen phosphorylase activity (GO:0008184) # cellular_component 20150305: node_PTN000157685 is found in cytoplasm (GO:0005737) # biological_process 20150305: node_PTN000157685 participates in glycogen catabolic process (GO:0005980) # PRUNED 24 Mar 2016: node_PTN000157824 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 14 Mar 2016: node_PTN000157824 has been pruned from tree Pruned the top part of the tree. MF -pyridoxal phosphate is a coenzyme derived from vitamin B6. There are annotations in only to the muscle form of the enzyme, but based on the alignment, it is likely that the coenzyme is used by all three forms of the enzyme. Actually, the human liver form binds to PLP, but is annotated to vitamin binding. So the term is propagate to the root 5-March-2015, HM # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).